Prediabetes - Symptoms and causes

Causes and symptoms of prediabetes

Discover the causes, symptoms, and relationship between prediabetes and microbiota, and how probiotics can provide significant benefits. Explore this comprehensive article to understand prediabetes and learn how you can improve your health.




Welcome to our informative article on prediabetes, a condition that affects millions of individuals in the United States. In this article, we will delve into the causes, symptoms, and the intriguing relationship between prediabetes and the microbiota. Additionally, we will explore how probiotics, the "good" bacteria, can play a vital role in managing and preventing prediabetes.


What is Prediabetes?


Prediabetes is a metabolic condition characterized by higher-than-normal blood glucose levels that are not yet classified as diabetes. Individuals with prediabetes have blood sugar levels that are higher than normal but not high enough to be diagnosed with type 2 diabetes. It is a critical stage where interventions can prevent the progression of full-blown diabetes.


Causes of Prediabetes


Several factors can contribute to the development of prediabetes. Here are some common causes:


  • Insulin resistance: Insulin is a hormone produced by the pancreas that helps regulate blood sugar levels. In prediabetes, cells become resistant to the effects of insulin, causing the pancreas to produce more insulin to compensate. Over time, the pancreas may struggle to keep up with the increased demand, leading to higher blood sugar levels.
  • Sedentary lifestyle: Lack of physical activity and a sedentary lifestyle are significant risk factors for prediabetes. Regular exercise helps improve insulin sensitivity, allowing cells to use blood sugar more effectively. Inactivity, on the other hand, can contribute to weight gain and insulin resistance.
  • Excess weight and obesity: Being overweight or obese significantly increases the risk of developing prediabetes. Extra body fat, especially around the abdomen, can interfere with insulin function and lead to insulin resistance.
  • Unhealthy diet: Consuming a diet high in refined carbohydrates, sugary beverages, and processed foods can contribute to the development of prediabetes. These foods can cause rapid spikes in blood sugar levels, putting strain on the body's insulin response.
  • Family history and genetics: Having a family history of type 2 diabetes or prediabetes can increase an individual's risk of developing the condition. Genetic factors can influence insulin resistance and the overall risk of developing metabolic disorders.
  • Ethnicity: Certain ethnic groups, such as African Americans, Hispanic/Latino Americans, Native Americans, and Asian Americans, have a higher risk of developing prediabetes and type 2 diabetes.
  • Age: Prediabetes becomes more common with age. The risk increases after the age of 45, partly due to reduced physical activity and muscle mass.


It is important to note that while these factors contribute to the development of prediabetes, they do not guarantee its occurrence. Lifestyle changes, such as adopting a healthy diet, engaging in regular physical activity, and maintaining a healthy weight, can help prevent or delay the progression from prediabetes to type 2 diabetes. Regular check-ups with a healthcare provider are essential for early detection and management of prediabetes.


Symptoms of Prediabetes


While prediabetes may not present any noticeable symptoms in its early stages, certain signs and symptoms may indicate its presence. These can include:


  • Increased thirst: Feeling excessively thirsty, even after drinking an adequate amount of fluids.
  • Frequent urination: Needing to urinate more frequently, especially during the night.
  • Fatigue: Experiencing constant tiredness or lack of energy, even after sufficient rest.
  • Increased hunger: Feeling hungry more often, particularly craving sugary and starchy foods.
  • Weight changes: Unexplained weight loss or gain may occur in some individuals.
  • Blurred vision: Experiencing difficulties with clear vision, often accompanied by eyestrain or headaches.
  • Slow-healing sores or frequent infections: Wounds or cuts taking longer to heal or recurring infections, such as urinary tract or yeast infections.


The Relationship between Prediabetes and the Microbiota


The microbiota encompasses a vast collection of microorganisms, which includes bacteria, viruses, fungi, and other microbes. These organisms reside primarily in our gastrointestinal tract and play a significant role in maintaining our overall health. Various aspects of human physiology, such as metabolism and immune function, have been associated with the microbiota.


In individuals with prediabetes, there is a notable decrease in the abundance of specific beneficial bacteria, such as those found in the Bifidobacterium genera. These bacteria are essential for preserving the integrity of the gut barrier, producing short-chain fatty acids (SCFAs), and regulating inflammation. The reduced levels of these bacteria in individuals with prediabetes may contribute to disturbances in metabolic regulation and insulin resistance.


Furthermore, changes in the gut microbiota of individuals with prediabetes can affect the way dietary nutrients are metabolized. Several studies have indicated that individuals with prediabetes have an altered ability to ferment dietary fibers, leading to modifications in SCFA production. SCFAs serve as vital sources of energy for the cells that line the colon and have demonstrated influences on insulin sensitivity and glucose metabolism.


How Probiotics Benefit Prediabetes


Here are some ways in which probiotics can be beneficial for individuals with prediabetes:


  • Enhanced glucose metabolism: Various studies have shown that specific strains of probiotics can enhance insulin sensitivity and regulate blood sugar levels. By improving the body's ability to utilize insulin effectively, probiotics may help prevent the progression from prediabetes to type 2 diabetes.
  • Reduced inflammation: Individuals with prediabetes often experience chronic low-grade inflammation, which contributes to insulin resistance. Probiotics can modulate the immune response and reduce inflammation in the body, potentially improving insulin sensitivity and overall metabolic health.
  • Improved gut barrier function: The gut barrier is responsible for selectively allowing nutrients to pass through while preventing harmful substances from entering the bloodstream. Disruption of the gut barrier has been linked to metabolic disorders, including prediabetes. Probiotics can help maintain the integrity of the gut barrier, reducing the risk of metabolic dysfunction.
  • Regulation of gut microbiota: The gut microbiota, consisting of trillions of microorganisms in the digestive tract, has a significant impact on metabolism and overall health. Certain probiotic strains can positively influence the composition and diversity of the gut microbiota, creating a favorable environment for metabolic health.
  • Weight management: Excess body weight is a common risk factor for prediabetes and diabetes. Research has indicated that probiotics may contribute to weight loss or weight management by influencing appetite regulation, increasing energy expenditure, and promoting the utilization of dietary fats.
  • Blood pressure control: Hypertension (high blood pressure) is often associated with prediabetes and can increase the risk of cardiovascular complications. Some probiotic strains, particularly those from the Lactobacillus and Bifidobacterium genera, have been found to help reduce blood pressure.



How can probiotics be incorporated into the diet of a prediabetic?


Probiotics can be incorporated into the diet of a prediabetic by consuming probiotic supplements. It is important to choose high-quality probiotic products with strains suitable for blood sugar control.




Prediabetes is a significant health concern affecting a large portion of the population in the United States. Understanding the causes, recognizing the symptoms, and exploring the intriguing relationship between prediabetes and the microbiota is crucial for effective management and prevention. Incorporating probiotics into a prediabetic's diet can provide valuable benefits by promoting healthy gut microbiota, reducing inflammation, and improving insulin sensitivity.


Remember, prediabetes is a reversible condition, and with proper lifestyle changes, including a balanced diet, regular exercise, and potentially incorporating probiotics, individuals can make positive strides toward better health.


Remember that, as part of improving your lifestyle habits, it is advisable to consume probiotics to treat prediabetes. Make sure that, when including them in your diet, you choose those that contain the appropriate strains for the treatment, such as Bifidobacterium.


We recommend Xaviax CW probiotic, which contains Bifidobaterium lactis, agave inulin as a prebiotic and green coffee extract as a nutrient. This probiotic helps to inhibit glucose absorption and decreases body fat percentage. It is suitable to prevent and treat prediabetes.


By taking proactive measures and making informed choices, we can mitigate the risks associated with prediabetes and pave the way for a healthier future. Let's prioritize our well-being and work towards a world with fewer cases of prediabetes and diabetes.


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  • Mayo Clinic. (2022, January 25). Prediabetes. Retrieved from
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  • Barengolts, E. (2019). Gut microbiota, prebiotics, probiotics, and synbiotics in management of prediabetes. Journal of Clinical Endocrinology & Metabolism, 104(12), 5675-5693.
  • Yadav, H., Lee, J. H., Lloyd, J., Walter, P., & Rane, S. G. (2013). Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. Journal of Biological Chemistry, 288(35), 25088-25097.
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